李慧颖

     李慧颖，副教授，研究生导师。截至2024年2月，发表SCI论文60余

篇，其中以第一和通讯作者发表46篇（累计影响因子约300，他引630余

次）。主持或参与多项国家级、省部级项目和百万级横向项目，主持项

目总经费470万元。申请国家发明专利19项，第一发明人8项。参与编写

著作8部。

研究方向：

食品营养与人类慢病防治（具有生物学、食品科学、基础医学、药学和生物信息学交叉研究背景）；食品功能评价及相关机制研究；药品和保健食品研发
教育及工作经历：

2011年毕业于清华大学生命科学学院（生物学博士）；
2015年生物信息学国家重点实验室（清华大学信息学院）博后出站；
2016年7月至2022年7月，中国农科院北京牧医所工作；
2022年7月至今，ManBetX中国官网生物学院工作。
学术任职：

《Chinese Medicine》、《Frontiers in Physics》等期刊任编委和编辑；
中国功能食品产业联盟专家；
中国营养与健康智库专家；
北京市科协“千人进千企”产业特派员；
北京中研子创科技公司首席科学家；
科优睿博（北京）科技有限公司首席科学家；等。
近5年获省部级奖项：

国家林草局第五批林草科技创新青年拔尖人才（2023年）
神农中华农业科技奖（创新团队类成果）优秀创新团队奖第8名（ 2018-2019年）
神农中华农业科技奖（科学研究类成果）一等奖第19名（2018-2019年）
长城食品安全科学技术奖特等奖“优质乳生产的品质提升与绿色低碳工艺 关键技术”第7名（2018年）
近年在天然成分领域以第一/通讯作者文章发表的部分SCI论文

Extraction condition optimization, quantitative analysis and anti-diabetes bioactivities evaluation of acorn polysaccharides from three different species. Food Chemistry: X, 2024.

Evaluation of the Protective Bioactivity and Molecular Mechanism Verification of Lactoferrin in an Alzheimer's Mouse Model with Ulcerative Enteritis. Journal of Dairy Science, 2024.

The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model. CNS Neuroscience & Therapeutics, 2024.

Circadian rhythm disruption leads to the progression of Alzheimer's disease through regulating m6A methylation of key gene Hif3α. CNS Neuroscience & Therapeutics, 2024.

Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments. Chinese Medicine, 2023.

Anthracycline Chemicals with an-Thracyclinone Structure Exert Antitumor Effects by Inhibiting Angiogenesis and Lymphangiogenesis in A Xenografted Gastric Tumor Model. Gastric Cancer, 2023.

Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis. Journal of Translational Medicine, 2023.
Milk Active Ingredients, 2 ‘-fucosyllactose Inhibits Inflammation and Promotes MUC2 Secretion in LS174T Goblet Cells in vitro. Foods, 2022.

Lactoferrin inhibits the development of T2D to colon tumors by regulating NT5DC3/PI3K/AKT/mTOR signaling pathway. Foods, 2022.

Dynamic Regulation of eEF1A1 Acetylation Affects Colorectal Carcinogenesis. Biological Chemistry, 2022.

Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer. Frontiers in Immunology, 2022.

Lactoferrin Alleviates Lipopolysaccharide-induced Infantile Intestinal Immune Barrier Damage By Regulating ELAVL1-related Signaling Pathway. International Journal of Molecular Sciences, 2022.

2’-Fucosyllactose Suppresses Angiogenesis and Alleviates Toxic Effects of 5-Fu in a HCT116 Colon Tumor-Bearing Model. Molecules, 2022.

2’-fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression. Frontiers in Nutrition, 2022.

Protective effects of recombinant lactoferrin with different iron saturations on enteritis injury in young mice. Journal of Dairy Science, 2022.

Baicalin suppresses the progression of Type II diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Caspase3 pathway. PHYTOmedicine, 2021.

Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway. International Immunopharmacology, 2021.

The crosstalking between gut microbiome and immune response regulated by diet nutrients in inflammatory bowel disease. Foods, 2021.

Lactoferrin could alleviate liver injury caused by Maillard reaction products with furan ring through regulating necroptosis pathway. Food Science & Nutrition, 2021.

The combination of lactoferrin and linolenic acid inhibits colorectal tumor growth through activating AMPK/JNK-related apoptosis pathway. Peer J, 2021.

Inhibitory effect of lactoferrin on pulmonary inflammatory process induced by lipopolysaccharide through modulating TLR4-related pathway. Journal of Dairy Science, 2021.

Angustoline Inhibited Esophageal Tumors Through Regulating LKB1/AMPK/ELAVL1/LPACT2 Pathway And Phospholipid Remodeling. Frontiers in Oncology, 2020.

Maillard reaction products with furan ring, like furosine, cause kidney injury through triggering ferroptosis pathway. Food Chemistry, 2020.

Investigation and comparison of the protective activities of three functional proteins-lactoferrin, α-lactalbumin, and β-lactoglobulin in cerebral ischemia reperfusion injury. Journal of Dairy Science, 2020.

The combination of two bioactive constituents, lactoferrin and linolenic acid, inhibits mouse xenograft esophageal tumor growth by downregulating lithocholyltaurine and inhibiting the JAK2/STAT3-related pathway. ACS Omega, 2020.

Toxic effects of furosine by oral intake on liver and kidney and toxicokinetics research in mice acute toxicity model. Food Science and Technology Science, 2020.

Modulation activity of heat-treated and untreated lactoferrin on the TLR-4 pathway in anoxia cell model and cerebral ischemia reperfusion mouse model. Journal of Dairy Science, 2019.

Furosine, a Maillard Reaction Product, Triggers Necroptosis in Hepatocytes by Regulating the RIPK1/RIPK3/MLKL Pathway. International Journal of Molecular Sciences, 2019.

Investigation and comparison of the anti-tumor activities of lactoferrin, α-lactalbumin and β-lactoglobulin, in A549/HT29/HepG2/MDA231-LM2 tumor models. Journal of Dairy Science, 2019.

L-proline alleviates kidney injury caused by AFB1 and AFM1 through regulating excessive apoptosis of kidney cells. Toxins, 2019.

Lactoferrin induces the synthesis of vitamin B6 and protects HUVEC functions by activating PDXP and the PI3K/AKT/ERK1/2 pathway. International Journal of Molecular Sciences, 2019.

Furosine Posed Toxic Effects on Primary Sertoli Cells through Regulating Cep55/NF-kappa B/PI3K/Akt/FOX01/TNF-alpha Pathway. International Journal of Molecular Sciences, 2019.

Effect of heat treatment on the anti-tumor activity of lactoferrin in human colon tumor (HT29) model. Journal of Agricultural and Food Chemistry, 2019.

Toxicology studies of furosine in vitro/in vivo and exploration of the related mechanism. Toxicology Letters, 2018.

The toxic effects of aflatoxin B1 and aflatoxin M1 on kidney through regulating L-proline and downstream apoptosis. Biomed Research International, 2018.

Furosine induced apoptosis by the regulation of STAT1/STAT2 and UBA7/UBE2L6 genes in HepG2 cells. International Journal of Molecular Sciences, 2018.

Lactoferrin exerts anti-tumor effects by inhibiting angiogenesis in a HT29 human colon tumor model. Journal of Agricultural and Food Chemistry, 2017.
近年来以第一发明人申请专利
1 临床肝移植和急性胰腺炎病人全营养代餐粉成分组合，第一发明人，提交申请
2 一种高程度保留预制菜品营养成分的加工工艺及感官评价方法，第一发明人，提交申请
3一种液氮冻存肿瘤组织构建 PDX 模型的构建方法及其试剂组合，第一发明人，实审
4 一种改良的 PDX 模型构建方法及其试剂组合，第一发明人，实审
5 一种高通量检测人NT5DC3 蛋白的高灵敏 ELISA 试剂盒, 第一发明人，实审
6 一种抗癌症的药物组合物，第一发明人（202010176118.5），已授权
7 一种包含乳蛋白和油酸的药物组合物，第一发明人（201911193771.6），已授权
8 一种抗癌症的药物组合物，第二发明人（201911193760.8），已授权